Focusing on three strategic directions of TCM modernization, integrating nanotechnology, tissue engineering, and modern medicine to conduct full-chain innovative research from basic studies to clinical translation.
Targeting major viral infectious diseases, we deeply explore the antiviral active components and mechanisms of TCM, constructing novel intervention strategies based on inflammatory microenvironment regulation.
Systematically screen and validate antiviral lead compounds from TCM sources, elucidating their molecular targets and signaling pathways for directly inhibiting viral replication or blocking viral entry.
Explore the key mechanisms by which TCM modulates innate and adaptive immune responses, constructing a dual-action model of 'antiviral + immunomodulation'.
Targeting the excessive inflammatory response in severe viral infections, developing TCM intervention strategies targeting key inflammatory pathways.
TCM chemical database construction Virtual screening & molecular docking
Cell model construction Antiviral activity evaluation
Molecular target identification Signaling pathway analysis
Animal infection models Preclinical research
Discovered multiple TCM-derived natural products that effectively inhibit SARS-CoV-2 replication, elucidating their immunomodulatory mechanisms through transcriptomics...
Developed an inhalable TCM polysaccharide-based nanohydrogel that prolongs drug retention in the lungs and enhances local antiviral effects...
Employed a combined strategy of network pharmacology and experimental validation to reveal the multi-target synergistic mechanisms of classical anti-influenza TCM formulas...